BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX
نویسندگان
چکیده
منابع مشابه
Sequence and helicity requirements for the proapoptotic activity of Bax BH3 peptides.
Overexpression of the antiapoptotic proteins Bcl-2 and Bcl-XL is commonly observed in human malignancies and contributes to chemotherapy and radiation resistance. Bcl-2 and Bcl-XL inhibit apoptosis by binding to proapoptotic proteins such as Bax, thereby preventing chemotherapy-induced or radiation-induced release of cytochrome c from mitochondria and subsequent activation of the caspase protea...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2010
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2010.10.019